RRs (95% CI) away from full, ischemic, and you can hemorrhagic strokes because of the quintiles out of joint diet ratings to possess magnesium, potassium, and you can calcium consumption when you look at the 86,149 feamales in new NHS We and you can 94,715 ladies in the brand new NHS II step 1
We upgraded the new meta-analyses off prospective education out-of losing weight magnesium ( 21), potassium ( 22), and you can calcium ( 23) intakes and threat of coronary arrest
The multivariate model was adjusted for age, calendar year, total calories (quintiles of kcal), BMI (in kg/m 2 ; <25, 25 to <30, or ?30), parental history of heart disease (aged ?60 y), alcohol intake (0, 0 to <5, 5 to <10, 10 to <15, or ?15 g/d), physical activity (<3, 3 to <9, 9 to <18, 18 to <27, or ?27 metabolic equivalent tasks/wk), smoking, postmenopausal hormone therapy, oral contraceptive use (never, past, or current), menopausal status (premenopausal or postmenopausal), aspirin (0 to <2 or ?2 pills/wk), multivitamin, history of hypertension, hypercholesterolemia, diabetes at baseline, and thiazide use (yes or no). NHS, Nurses' Health Study.
RRs (95% CI) out-of complete, ischemic, and you will hemorrhagic strokes of the quintiles regarding joint eating plan scores for magnesium, potassium, and you will calcium supplements consumption in 86,149 ladies in the NHS I and you will 94,715 women in this new NHS II step one
We updated the fresh meta-analyses off potential training regarding weight-loss magnesium ( 21), potassium ( 22), and you can calcium ( 23) intakes and you will likelihood of coronary arrest
The multivariate model was adjusted for age, calendar want Muslim Sites dating site reviews year, total calories (quintiles of kcal), BMI (in kg/m 2 ; <25, 25 to <30, or ?30), parental history of heart disease (aged ?60 y), alcohol intake (0, 0 to <5, 5 to <10, 10 to <15, or ?15 g/d), physical activity (<3, 3 to <9, 9 to <18, 18 to <27, or ?27 metabolic equivalent tasks/wk), smoking, postmenopausal hormone therapy, oral contraceptive use (never, past, or current), menopausal status (premenopausal or postmenopausal), aspirin (0 to <2 or ?2 pills/wk), multivitamin, history of hypertension, hypercholesterolemia, diabetes at baseline, and thiazide use (yes or no). NHS, Nurses' Health Study.
We examined separately the relation between intakes of magnesium, potassium, and calcium from supplements and risk of stroke. There was no significant association between supplemental magnesium or calcium intake and risk of total, ischemic, or hemorrhagic stroke in the pooled analyses. We observed a significant inverse association between supplemental potassium intake and risk of ischemic but not total or hemorrhagic stroke. The pooled multivariate RR for comparison of highest with lowest quintiles of supplemental potassium intake was 0.71 (95% CI: 0.56, 0.89, P-trend < 0.01) for ischemic stroke. Pooled multivariate RRs for supplemental magnesium (Supplemental Table 7), supplemental potassium (Supplemental Table 8), and supplemental calcium (Supplemental Table 9) and risk of total, ischemic, and hemorrhagic strokes are shown in the supplemental material.
We examined total and you may losing weight intakes each and every nutrient and chance regarding stroke to decide any potential nonlinear organization that with restricted cubic splines; not, zero significant departure regarding linearity is seen. Likewise, we looked the potential perception amendment by the ages, blood pressure level, otherwise diabetic issues towards relatives ranging from full consumption of all step 3 nutrition and likelihood of full coronary arrest. Zero high impression amendment is actually noticed from the this type of issues.
Previous meta-analyses provided is a result of earlier in the day analyses regarding NHS ( 10); these types of show was in fact replaced by the contributes to the present day investigation. Likewise, brand new literary works is actually searched, and recent possible education ( 8, 24) have been utilized in these types of current meta-analyses. No ranging from-degree heterogeneity was noticed for the of your step three nutrients. The fresh new joint RR regarding complete coronary arrest is 0.87 (95% CI: 0.83, 0.92) to own a hundred-mg/d improve off magnesium consumption, 0.91 (95% CI: 0.88, 0.94) to own a great a thousand-mg/d improve out of potassium consumption, and 0.98 (95% CI: 0.94, 1.02) having a three hundred-mg/d boost away from calcium intake.